GroupDocs.AnnotatiOn for PythOn via .NET adds, edits, and removes annotatiOns and markup — area and shape annotatiOns, text highlight/underline/strikeout, watermarks, image and link stamps, and threaded comments — On PDF, DOCX, XLSX, PPTX, images, CAD, Visio, and email files, entirely On-Premise without Microsoft Office.... It runs entirely on-premise, requires no Microsoft Office...